This strategy, known as angiogenesis inhibition, is the basis for more than 15 drugs used to treat cancers of the brain, colon, lungs and kidneys. The new study, reported in the journal Science Translational Medicine, is the first to test the strategy in primates as a treatment for obesity. After four weeks of daily injections of adipotide and a four-week follow-up with no treatment and without forced changes in diet or exercise 10 obese female rhesus macaques lost an average of 11% of body weight and 39% of fat deposits. Much of that loss came in the three weeks after the drug was discontinued, during which the treated macaques continued to become lighter and leaner.
For the original version including any supplementary images or video, visit http://articles.latimes.com/2011/nov/10/health/la-he-drug-fat-loss-20111110
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